First1000's content is so great it should be a best-selling book, in the spirit of Founders At Work.
I could probably just stop at saying it's one of a tiny handful of newsletters I actively seek out each week (as in, go hunting in Promotions or Spam if I can't find it).
The writing has delightful zest and the author makes it really simple to understand what made the biggest products today actually get off the ground... It's a rare combo of practical and inspirational.
My only grumble is I typically want *more* at the end of every issue :-)